The role of psycho-emotional component of stress effect in response of hemostasis system to graded exercise in experiment

The role of psycho-emotional component of stress effect in response of hemostasis system to graded exercise in experiment


PhD O.V. Alekseeva1
PhD Y.A. Bondarchuk1, 2
Dr.Med., Associate Professor I.I. Shakhmatov1, 2
А.А. Blazhko1
S.V. Moskalenko1
1Altai State Medical University, Barnaul
2Scientific Research Institute of Physiology and Basic Medicine (PhBMRI), Novosibirsk

The hemostasis system changes under the influence of the psycho-emotional component of the stress effect within a single physical activity have been studied. The studies were performed in male laboratory mature Wistar rats (n = 98), which comprised two experimental groups differing in the type of stress effect and a control group of intact animals. Physical activity alone (treadmill walking) and psycho-emotional stress and physical activity combined (swimming with additional weight on the tail) were used as stress factors.
The results of the study showed that a single two-hour physical activity leads to platelet and plasma hemostasis activation, anticoagulant system and fibrinolysis suppression.
The combination of physical activity and psycho-emotional stress (two-hour swimming with additional weight) causes the activation of platelet and coagulation hemostasis with the threat of intravascular thrombus formation as thrombinemia, a decrease in fibrinogen amount, in anticoagulant system activity and activation of fibrinolytic system of blood plasma.

Keywords: psycho-emotional stress, physical activity, hemostasis.


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