Yun Yufen
The National Research Tomsk State University, Tomsk

Milovanova K.G.
The National Research Tomsk State University, Tomsk

Dyakova E.Yu.
The National Research Tomsk State University, Tomsk

Qu Xianbo
The National Research Tomsk State University, Tomsk

Objective of the study is to systematically assess the effect of physical exercise on the function of the mitochondrial oxidative phosphorylation system (OxPhos) in patients with type 2 diabetes mellitus.
Methods and structure of the study. The meta-analysis included 13 scientific publications selected from the international databases Web of Science and PubMed. Statistical analysis was performed using Stata version 16.0.
Results and conclusions. The obtained data showed that physical training promotes activation of the oxidative phosphorylation system in skeletal muscles of patients with diabetes mellitus, increasing the efficiency of mitochondrial energy metabolism. The most pronounced positive effect on the OxPhos complex was revealed during combined training (aerobic and strength training), while strength exercises more effectively increased the level of citrate synthase (CS). Physical activity improves mitochondrial function due to activation of oxidative phosphorylation processes in patients with diabetes mellitus. Strength training, as well as its combination with aerobic exercise, can be considered as a promising non-drug strategy for correcting metabolic disorders in skeletal muscles.

Keywords: type 2 diabetes mellitus; physical exercise; mitochondria; oxidative phosphorylation; skeletal muscles.

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