Polymorphism of the COL5A1 gene and biomechanical characteristics of the muscles of the lower extremities of young athletes involved in wushu-taolu

ˑ: 

PhD, Associate Professor N.D. Golberg1
Dr. Hab. V.F. Noskova1
Yu.S. Shchurova1
PhD E.V. Valeeva2
1Saint-Petersburg scientific-research institute for physical culture, St. Petersburg
2Kazan Medical University, Kazan

Objective of the study was to reveal the distribution of genotypes and alleles of the Col5A1 gene in young Wushu Taolu athletes and their associations with the biomechanical characteristics of muscles.
Methods and structure of the study. The study involved athletes involved in uschu-taolu. The surveyed athletes trained at two adjacent stages - the stage of sports specialization (n=42) and the stage of improving sportsmanship (n=34). Polymorphism of the Col5A1 gene was determined using molecular genetic analysis.
Results and conclusions. The viscoelastic properties of the muscles of the lower extremities were assessed and it was found that with increasing fitness, there is an association between muscle stiffness and carriage of the T allele of the COL5A1 gene, which indicates the formation of a certain sports phenotype based on the genotype of athletes.

Keywords: Col5A1 gene polymorphism, viscoelastic properties of muscles, muscle stiffness, fitness, wushu athletes.

References

  1. Shitova E.S., Heregey A.M., Suvorov V.G., Sotin A.V. Vliyaniye lokalnogo myshechnogo utomleniya na biomekhanicheskiye i vyazkouprugiye kharakteristiki skeletnykh myshts [The influence of local muscle fatigue on the biomechanical and viscoelastic characteristics of skeletal muscles]. Rossiyskiy zhurnal biomekhaniki. 2021. Vol. 25. No. 4. pp. 444-455.
  2. Ahmetov I.I., Hall E.C.R., Semenova E.A., Pranckevičienė E., Ginevičienė V. Advances in sports genomics. Adv. Clin. Chem. 2022. Vol. 107. pp. 115-263.
  3. Collins M., Raleigh S.M. Genetic risk factors for musculoskeletal soft tissue injuries. Med Sport Sci. 2009. Vol. 54. pp. 136-149.
  4. Collins M., Posthumus M. Type V collagen genotype and exercise-related phenotype relationships: a novel hypothesis. Exerc. Sport Sci. Rev. 2011. Vol. 39. pp. 191-198.
  5. Collins M., Connell O’ K., Posthumus M. Genetics of musculoskeletal exercise-related phenotypes. Med. Sport Sci. 2016. Vol. 61. pp. 92-104.
  6. Gavronski G., Veraksitš A., Vasar E., Maaroos J. Evaluation of viscoelastic parameters of the skeletal muscles in junior triathletes. Physiol. Meas. 2007. Vol. 28. pp. 625-637.
  7. Gen-Expert (2013) Genetic expertise. Available at: https://calc.pcr24.ru/index.php (date of access: 02.09.2022).
  8. Hoffman L.R., Koppenhaver S.L., McDonald C.W., Herrera J.M. et al. Normative parameters of gastrocnemius muscle stiffness and associations with patient characteristics and function. J. Sport Phys. Ther. 2021. Vol. 16. pp. 41-48.
  9. Lee Y., Kim M., Lee H. The measurement of stiffness for major muscles with shear wave elastography and myoton: a quantitative analysis study. Diagnostics. 2021. Vol. 11. Article no. 524.
  10. Lim S.T., Kim C.S., Kim W.N., Min S.K. The COL5A1 genotype is associated with range of motion. J. Exerc. Nutr. Biochem. 2015. Vol.19. pp. 49-53.
  11. Melo A.S.C., Cruz E.B., Vilas-Boas J.P., Sousa A.S.P. Scapular dynamic muscular stiffness assessed through myotonometry: a narrative review. Sensors. 2022. Vol. 22. Article no. 2565.