Myostatin as "bodybuilding gene" (brief overview)

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Dr. Hab., Associate Professor M.O. Aksenov1, 2
E.A. Krylasova2
PhD I.I. Starkova2
Postgraduate A.O. Zaitseva2
1Plekhanov Russian University of Economics, Moscow
2Banzarov Buryat State University, Ulan-Ude

Objective of the study was to analyze the latest scientific research to identify associations of the K153R polymorphism in the myostatin (MSTN) gene (rs1805086) with skeletal muscle hypertrophy and athletes’ strength.
Methods and structure of the study. The research articles to be analyzed were searched in the databases of PubMed, WebofScience, eLIBRARY.ru, SNPedia, Wiley Online Library, and Europe PMC resource. The following keywords were used during the search: myostatin, MSTN, GDF-8, K153R, rs1805086. We compiled a list of publications about myostatin, including 81 scientific papers published in the above databases before February 2020. We used Clarivate Analytics’s EndNote Viever X9.2 software to analyze and systematize the publications.
Results and conclusions. It is only in the past 15 years that genetic polymorphisms controlling the skeletal muscle mass and function in athletes, and the mechanisms of their manifestation within the phenotype have begun to be clarified. It is not surprising that new mechanisms and associations of these genes continue to be discovered, and indeed, there has recently been considerable progress in this area. Besides, the discovery of genes that significantly improve the aptitude for sports, such as myostatin, will significantly enhance the quality of sports selection and orientation.

Keywords: sports, training, systematic review, myostatin, skeletal muscles, gene, strength, athletic training, hypertrophy, MSTN, K153R, rs1805086.

References

  1. Aksenov M.O. and Andryushchenko L.B. (2018). Myostatin gene role in strength building process. In: Teoriya i Praktika Fizicheskoy Kultury, Vol. 4, pp. 71-73.
  2. Allen D.L., Hittel D.S. and McPherron, A.C. (2011) Expression and Function of Myostatin in Obesity, Diabetes, and Exercise Adaptation. Medicine and Science in Sports and Exercise 43, 1828-1835, Oct.
  3. Ben-Zaken S., Meckel Y., Nemet D. and Eliakim, A. (2017) The combined frequency of IGF and myostatin polymorphism among track & field athletes and swimmers. Growth Hormone & Igf Research 32, 29-32, Feb.
  4. Dalbo V.J., Roberts M.D., Sunderland K.L., Poole C.N., Stout J.R., Beck T.W., Bemben M. and Kerksick C.M. (2011) Acute Loading and Aging Effects on Myostatin Pathway Biomarkers in Human Skeletal Muscle After Three Sequential Bouts of Resistance Exercise. Journals of Gerontology Series a-Biological Sciences and Medical Sciences 66, 855-865, Aug.
  5. Ferrell, R.E., Conte, V., Lawrence, E.C., Roth, S.M., Hagberg, J.M. and Hurley, B.F. (1999) Frequent sequence variation in the human myostatin (GDF8) gene as a marker for analysis of muscle-related phenotypes. Genomics 62, 203-207, Dec.
  6. Fuku, N., Alis, R., Yvert, T., Zempo, H., Naito, H., Abe, Y., Arai, Y., Murakami, H., Miyachi, M., Pareja-Galeano, H., Emanuele, E., Hirose, N. and Lucia, A. (2016) Muscle-Related Polymorphisms (MSTN rs1805086 and ACTN3 rs1815739) Are Not Associated with Exceptional Longevity in Japanese Centenarians. Plos One 11, Nov.
  7. Garatachea, N., Pinos, T., Camara, Y., Rodriguez-Romo, G., Emanuele, E., Ricevuti, G., Venturini, L., Santos-Lozano, A., Santiago-Dorrego, C., Fiuza-Luces, C., Yvert, T., Andreu, A.L. and Lucia, A. (2013) Association of the K153R polymorphism in the myostatin gene and extreme longevity. Age 35, 2445-2454, Dec.
  8. Gonzalez-Freire, M., Rodriguez-Romo, G., Santiago, C., Bustamante-Ara, N., Yvert, T., Gomez-Gallego, F., Rexach, J.A.S., Ruiz, J.R. and Lucia, A. (2010) The K153R variant in the myostatin gene and sarcopenia at the end of the human lifespan. Age 32, 405-409, Sep.
  9. Ivey, F.M., Roth, S.M., Ferrell, R.E., Tracy, B.L., Lemmer, J.T., Hurlbut, D.E., Martel, G.F., Siegel, E.L., Fozard, J.L., Metter, E.J., Fleg, J.L. and Hurley, B.F. (2000) Effects of age, gender, and myostatin genotype on the hypertrophic response to heavy resistance strength training. Journals of Gerontology Series a-Biological Sciences and Medical Sciences 55, M641-M648, Nov.
  10. Kollias, H.D. and McDermott, J.C. (2008) Transforming growth factor-beta and myostatin signaling in skeletal muscle. Journal of Applied Physiology 104, 579-587, Mar.
  11. Li, X., Wang, S.J., Tan, S.C., Chew, P.L., Liu, L.H., Wang, L., Wen, L. and Ma, L.H. (2014) The A55T and K153R polymorphisms of MSTN gene are associated with the strength training-induced muscle hypertrophy among Han Chinese men. Journal of Sports Sciences 32, 883-891, May.
  12. McFarlane, C., Hui, G.Z., Amanda, W.Z.W., Lau, H.Y., Lokireddy, S., Ge, X.J., Mouly, V., Butler-Browne, G., Gluckman, P.D., Sharma, M. and Kambadur, R. (2011) Human myostatin negatively regulates human myoblast growth and differentiation. American Journal of Physiology-Cell Physiology 301, C195-C203, Jul.
  13. McPherron, A.C., Lawler, A.M. and Lee, S.J. (1997) Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature 387, 83-90, May.
  14. Roth, S.M., Martel, G.F., Ferrell, R.E., Metter, E.J., Hurley, B.F. and Rogers, M.A. (2003) Myostatin gene expression is reduced in humans with heavy resistance strength training: A brief communication. Experimental Biology and Medicine 228, 706-709, Jun.
  15. Santiago, C., Ruiz, J.R., Rodriguez-Romo, G., Fiuza-Luces, C., Yvert, T., Gonzalez-Freire, M., Gomez-Gallego, F., Moran, M. and Lucia, A. (2011) The K153R Polymorphism in the Myostatin Gene and Muscle Power Phenotypes in Young, Non-Athletic Men. Plos One 6, 5, Jan.
  16. Seibert, M.J., Xue, Q.L., Fried, L.P. and Walston, J.D. (2001) Polymorphic variation in the human myostatin (GDF-8) gene and association with strength measures in the Women's Health and Aging Study II cohort. Journal of the American Geriatrics Society 49, 1093-1096, Aug.
  17. Shishkin, S.S. (2004). Miostatin i nekotorye drugie biohimicheskie faktory, reguliruyushchie rost myshechnyh tkanej u cheloveka i ryada vysshih pozvonochnyh. In: Uspekhi biologicheskoj himii, Vol. 44, pp. 209-262.
  18. Thomis, M.A.I., Huygens, W., Heuninckx, S., Chagnon, M., Maes, H.H.M., Claessens, A.L., Vlietinck, R., Bouchard, C. and Beunen, G.P. (2004) Exploration of myostatin polymorphisms and the angiotensin-converting enzyme insertion/deletion genotype in responses of human muscle to strength training. European Journal of Applied Physiology 92, 267-274, Jul.
  19. Zheng, L.-F., Chen, P.-J. and Xiao, W.-H. (2019). Signaling pathways controlling skeletal muscle mass. In: Acta Physiologica Sinica, Vol. 71, pp. 671-679.